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Synfacts 2006(1): 0013-0013  
DOI: 10.1055/s-2005-921664
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-SCH 351338

Contributor(s): Philip Kocienski
S. Bolshakov, J. L. Leighton*
Columbia University, New York, USA
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

SCH-351448 is the first selective activator of the low-density lipoprotein (LDL) receptor and it has potential for clearing serum cholesterol by increasing LDL uptake. This is the third total synthesis of SCH-351448 reported to date. For the previous syntheses see: E. Lee et al. J. Org. Chem. 2005, 70, 6321-6329; O. Soltani, J. K. De Brabender Org. Lett. 2005, 7, 2791-2793.